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海洋桥梁工程 3

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

《医学前沿（英文）》 2021年 第15卷 第3期   页码 404-415 doi: 10.1007/s11684-021-0834-9

摘要： Zika virus (ZIKV) is an emerging pathogen associated with neurological complications, such as Guillain–Barré syndrome in adults and microcephaly in fetuses and newborns. This mosquito-borne flavivirus causes important social and sanitary problems owing to its rapid dissemination. However, the development of antivirals against ZIKV is lagging. Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines for the treatment (or prevention) of ZIKV infections are currently unavailable. Repurposing clinically approved drugs could be an effective approach to quickly respond to an emergency outbreak of ZIKV infections. The well-established safety profiles and optimal dosage of these clinically approved drugs could provide an economical, safe, and efficacious approach to address ZIKV infections. This review focuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs. Their characteristics, targets, and potential use in anti-ZIKV therapy are presented. This review provides an update and some successful strategies in the search for anti-ZIKV agents are given.

关键词： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

《医学前沿（英文）》 doi: 10.1007/s11684-023-1037-3

摘要： The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection. So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivir, and molnupiravir have been marketed for the treatment of COVID-19. Nirmatrelvir–ritonavir has been recommended by the World Health Organization as an early treatment for outpatients with mild-to-moderate COVID-19. However, the existing treatment options have limitations, and effective treatment strategies that are cost-effective and convenient for tackling COVID-19 are still needed. To date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approval in China. These drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116). Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supported its early use in mild-to-moderate COVID-19 cases at high risk for progression. In this review, we discuss the most recent findings regarding the pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviral agents for COVID-19. These findings will expand our understanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs.

关键词： COVID-19     antiviral drugs     mindeudesivir    

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Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

《化学科学与工程前沿（英文）》 2016年 第10卷 第1期   页码 1-15 doi: 10.1007/s11705-016-1562-6

摘要： Natural products and their derivatives represent a rich source for the discovery and development of new cancer therapeutic drugs. Bioactive components derived from natural sources including marine compounds have been shown to be effective agents in the clinic or in preclinical settings. In the present review, we present a story of discovery, synthesis and evaluation of three synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs as cancer therapeutic agents. Chemical synthesis of these compounds (BA-TPQ, TBA-TPQ, and TCBA-TPQ) has been accomplished and the mechanisms of action (MOA) and structure-activity relationships (SAR) have been investigated. In the past, the complexity of chemical synthesis and the lack of well-defined MOA have dampened the enthusiasm for the development of some makaluvamines. Recent discovery of novel molecular targets for these alkaloids (unrelated to inhibition of Topoisomerase II) warrant further consideration as clinical candidates in the future. In addition to the establishment of novel synthetic approaches and demonstration of and anticancer activities, we have successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53 pathway, providing ample opportunities of modulating the compound structure based on SAR and the use of such compounds in combination therapy in the future.

关键词： synthesis     marine drugs     tricyclic pyrroloquinone alkaloid     cancer therapy     MDM2     p53    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

《环境科学与工程前沿（英文）》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1140-5

摘要：

We developed a method for determining 11 abused drugs in water and sediment.

METH and EPH were the dominant drugs in water and sediment in Beiyunhe River.

Abuse drugs in Beiyunhe River were mainly from hospitals and sewage effluents.

Abused drugs in the water would not impair the aquatic ecosystem biologically.

关键词： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Management strategies of marine food resources under multiple stressors with particular reference ofthe Yellow Sea large marine ecosystem

Qisheng TANG

《农业科学与工程前沿（英文）》 2014年 第1卷 第1期   页码 85-90 doi: 10.15302/J-FASE-2014021

摘要：

In this study two main management strategies are discussed: one is to develop resource conservation-based capture fisheries, and the other is to develop environmentally friendly aquaculture. During the resource recovery period, the development of environmentally friendly aquaculture should be encouraged, especially in integrated multi-trophic aquaculture, which is adaptive, efficient and sustainable. For future development and better understanding the ecosystem, it is necessary to further strengthen basic research.

关键词： marine     ecosystem     management strategies     food resources     Yellow Sea    

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海洋鱼类资源的可持续利用和海洋鱼类科学技术的研究方向

林浩然

《中国工程科学》 2003年 第5卷 第3期   页码 27-30

摘要：

积极实施海洋鱼类的增殖与养殖是海洋鱼类资源合理开发和可持续利用的基本措施和有效途径。因此，建立和提高海洋鱼类增殖与养殖的新技术，是近年来海洋生物技术的重要研究领域之一。海洋鱼类的生殖内分泌生理学、生长与发育生物学、免疫学、分子生物学等是海洋鱼类增殖与养殖的理论基础；系统深入地开展这些学科的基础研究和应用基础研究，成为当前海洋鱼类科学技术的前沿和主要发展方向。

关键词： 海洋鱼类资源     可持续利用     海洋鱼类增殖和养殖     海洋鱼类科学技术     海洋生物技术    

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Diversity and distribution of proteorhodopsin-containing microorganisms in marine environments

Bo WEI

《环境科学与工程前沿（英文）》 2012年 第6卷 第1期   页码 98-106 doi: 10.1007/s11783-010-0278-y

摘要： Proteorhodopsin (PR) is a recently discovered protein involved in the utilization of light energy. Several studies have shown that PR-containing microorganisms are widespread and compose a large proportion of the biomass in marine ecosystems. A better understanding of the ecological role of PR will help clarify the effect of the global flow of energy and the carbon cycle on marine communities. In this study, a bioinformatical database of PR codon sequences, the Global Distribution Database of Proteorhodopsin (GDDP), as a tool for analyzing the diversity and distribution of PR-containing microorganisms in marine environments throughout the world was designed. The community structure of PR microorganisms were also compared using PCR assays and UniFrac analyses of 12 samples collected from three water layers (0, 75, and 200 m) at four representative sites in the Pacific, Atlantic, and Indian Oceans. The results indicate that PR-containing microorganisms can be grouped into two distribution types: widespread and location-specific. Representative cases of the former include SAR11-PR and HOT2C01-PR. Interestingly, PR communities cluster by geographic locale but not by water depth.

关键词： proteorhodopsin (PR)     microorganism community     diversity     marine environments    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

《医学前沿（英文）》 2022年 第16卷 第5期   页码 815-826 doi: 10.1007/s11684-021-0891-0

摘要： Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL) due to their reliable efficacy, manageable safety, high accessibility, and convenience for use. Still, no guidelines or consensus focusing on oral drug therapies for BCL is available. To provide a reference of oral agent-based treatment for mature BCL, a panel of experts from the Lymphocyte Disease Group, Chinese Society of Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China, combined with the latest authoritative guidelines in the world and current research reports. This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients. With the deepening of research and the development of standardized clinical applications, oral medications will bring better treatment to BCL patients, enabling more patients to benefit from them.

关键词： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Demands and challenges for construction of marine infrastructures in China

Huajun LI; Yong LIU; Bingchen LIANG; Fushun LIU; Guoxiang WU; Junfeng DU; Huimin HOU; Aijun LI; Luming SHI

《结构与土木工程前沿（英文）》 2022年 第16卷 第5期   页码 551-563 doi: 10.1007/s11709-022-0839-8

摘要： The oceans are crucial to human civilization. They provide core support for exploitation and utilization of marine space, resources, and energy. Thus, marine infrastructures are vital to a nation’s economic sustainable development. To this end, this article first describes the main challenges in current ocean utilization, and then reviews the China’s ocean engineering progress. As such, six major sectors are evaluated: 1) global climate change and marine environment, 2) comprehensive utilization of marine space, 3) marine transportation infrastructure interconnection, 4) ocean clean energy development and maricultural facilities, 5) ecological crisis and marine engineering countermeasures, and 6) marine infrastructure operation safety and maintenance. Finally, perspectives on future directions of ocean utilization and marine infrastructure construction in China are provided.

关键词： marine infrastructures     ocean engineering     exploitation of marine resource     coastal development     emerging marine industries     technological challenges    

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Sensitivity analysis of the deterioration of concrete strength in marine environment to multiple corrosive

《结构与土木工程前沿（英文）》 2023年 第17卷 第2期   页码 175-190 doi: 10.1007/s11709-021-0791-z

摘要： The corrosion degradation behavior of concrete materials plays a crucial role in the change of its mechanical properties under multi-ion interaction in the marine environment. In this study, the variation in the macro-physical and mechanical properties of concrete with corrosion time is investigated, and the source of micro-corrosion products under different salt solutions in seawater are analyzed. Regardless of the continuous hydration effect of concrete, the damage effects of various corrosive ions (Cl–, SO42−, and Mg2+, etc.) on the tensile and compressive strength of concrete are discussed based on measurement in different salt solutions. The sensitivity analysis method for concrete strength is used to quantitatively analyze the sensitivity of concrete strength to the effects of each ion in a multi-salt solution without considering the influence of continued hydration. The quantitative results indicate that the addition of Cl– can weaken the corrosion effect of SO42− by about 20%, while the addition of Mg2+ or Mg2+ and Cl– can strengthen it by 10%–20% during a 600-d corrosion process.

关键词： sensitivity analysis     concrete strength     corrosion deterioration     multi-ion interaction     marine environment    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

《化学科学与工程前沿（英文）》 2014年 第8卷 第4期   页码 387-404 doi: 10.1007/s11705-014-1457-3

摘要： There are many challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs. Cell membrane presents one of the major barriers for the penetration of hydrophilic macromolecules across the plasma membrane. Nanocarriers have been designed to enhance their cellular uptake via endocytosis but following their cellular uptake, endosomal escape is the rate limiting step which restricts the value associated with the enhanced uptake by nanocarriers. Viruses are an excellent model for efficient cytosolic delivery by nanocarriers. Viruses exploit intracellular cues to release the genome to cytosol. In this review, we first discuss different endocytic uptake pathways and endosomal escape mechanisms. We then summarize the existing tools for studying the intracellular trafficking of nanocarriers. Finally, we highlight the important design elements of recent virus-based nanocarriers for efficient cellular uptake and endosomal escape.

关键词： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Hormesis-like growth and photosynthetic physiology of marine diatom Bohlin exposed to polystyrene microplastics

《环境科学与工程前沿（英文）》 2022年 第16卷 第1期   页码 2-2 doi: 10.1007/s11783-021-1436-0

摘要：

• Polystyrene microplastic caused hormesis-like effects in Phaeodactylum tricornutum.

关键词： Microplastics     Marine microalgae     Phaeodactylum tricornutum Bohlin     Growth     Photosynthetic pigments     Chlorophyll fluorescence parameters    

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蓝色海洋生物资源开发战略研究

“中国海洋工程与科技发展战略研究”海洋生物资源课题组

《中国工程科学》 2016年 第18卷 第2期   页码 32-40 doi: 10.15302/J-SSCAE-2016.02.004a

摘要：

为了提升海洋生物资源的开发能力，推进海洋强国的建设，中国工程院于2011年启动了“中国海洋生物资源工程与科技发展战略研究”重大咨询课题研究。课题从海水养殖、资源养护、远洋渔业、质量安全与加工流通、海洋药物与生物制品五个重要领域开展咨询调查研究，系统分析研究了发展现状、趋势和战略需求，提出了多层面地开发利用海洋生物资源的“养护、拓展、高技术”三大发展战略和推进蓝色海洋生物产业“可持续、安全、现代工程化”发展的三大战略目标及其任务，建议国家优先启动“蓝色海洋食物开发工程”和“蓝色海洋药物与生物制品关键技术开发工程”两个重点研发专项。

关键词： 蓝色海洋     生物资源开发     发展战略     研发专项    

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海洋科考装备技术发展战略研究

董胜,廖振焜,于立伟,李华军

《中国工程科学》 2023年 第25卷 第3期   页码 33-41 doi: 10.15302/J-SSCAE-2023.03.004

摘要：

海洋科考装备是发展海洋科学的重要基础。近年来我国自主研发的海洋科考装备接连取得突破，部分装备已达到国际先进水平，但依然存在诸多技术问题。本文以海洋科考装备发展战略需求为导向，围绕科考船、潜水器、浮标潜标、海洋传感器和海洋观测系统等调研国内外海洋科考装备发展现状；分析我国海洋科考装备技术发展在关键组件、技术发展、数据管理、基础保障、需求匹配等方面遇到的问题；总结面向深远海和极地的绿色化、无人化、智能化、协同化的未来发展趋势；梳理总体和各分类装备发展中需要注重的关键核心技术。在此基础上，从梳理短板技术重点突破、加强统筹协同提高保障能力、完善创新机制促进多学科交叉融合、强化市场思维推动产业化进程、依托先进科考平台拓展国际合作等方面提出发展建议，以期为进一步推动海洋科考装备快速发展提供参考。

关键词： 海洋科考；深海装备；极地海洋装备；海洋观测系统；智能化；装备研发    

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海洋生物技术与资源的可持续性利用

徐洵

《中国工程科学》 2000年 第2卷 第8期   页码 40-42

摘要：

海洋是地球上最大的生物资源库，它不仅提供人类优质蛋白质，还蕴藏有结构新颖、性能独特的生物活性物质。由于海洋环境的严酷性和条件的特殊性，开发海洋资源难度较大，只有利用现代生物技术，特别是关键的基因工程技术，才有可能持续地发展和利用海洋生物资源，从而为解决21世纪人类资源匮乏的问题开创新路。本文以长期困扰对虾养殖业的对虾白班杆状病毒为例，阐述了该病毒基因组研究的进展情况以及开展该病毒功能基因组研究的重要性。病毒的分子生物学研究将为防治养殖病害奠定基础。本文还强调了深海基因资源是一个有待开发的潜在宝库，是国际竞争的焦点之一，开展深海基因资源的研究在我国已刻不容缓。

关键词： 海洋生物技术     对虾白班杆状病毒     深海基因资源    

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标题 作者 时间 类型 操作

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

期刊论文

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

期刊论文

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

期刊论文

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

期刊论文

Management strategies of marine food resources under multiple stressors with particular reference ofthe Yellow Sea large marine ecosystem

Qisheng TANG

期刊论文

海洋鱼类资源的可持续利用和海洋鱼类科学技术的研究方向

林浩然

期刊论文

Diversity and distribution of proteorhodopsin-containing microorganisms in marine environments

Bo WEI

期刊论文

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

期刊论文

Demands and challenges for construction of marine infrastructures in China

Huajun LI; Yong LIU; Bingchen LIANG; Fushun LIU; Guoxiang WU; Junfeng DU; Huimin HOU; Aijun LI; Luming SHI

期刊论文

Sensitivity analysis of the deterioration of concrete strength in marine environment to multiple corrosive

期刊论文

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

期刊论文

Hormesis-like growth and photosynthetic physiology of marine diatom Bohlin exposed to polystyrene microplastics

期刊论文

蓝色海洋生物资源开发战略研究

“中国海洋工程与科技发展战略研究”海洋生物资源课题组

期刊论文

海洋科考装备技术发展战略研究

董胜,廖振焜,于立伟,李华军

期刊论文

海洋生物技术与资源的可持续性利用

徐洵

期刊论文